A Filterable Yeast-like Microorganism (schizosaccharomyces Filtrans, N. Sp.)

A Filterable Yeast-like Microorganism

Schizosaccharomyces pombe disaggregation machinery chaperones support Saccharomyces cerevisiae growth and prion propagation.

Hsp100 chaperones protect microorganisms and plants from environmental stress by cooperating with Hsp70 and its nucleotide exchange factor (NEF) and Hsp40 cochaperones to resolubilize proteins from aggregates. The Saccharomyces cerevisiae Hsp104 (Sc-Hsp104)-based disaggregation machinery also is essential for replication of amyloid-based prions. Escherichia coli ClpB can substitute for Hsp104 t...

Saccharomyces cerevisiae and Schizosaccharomyces pombe Contain a Homologue to the 54 - kD Subunit of The Signal Recognition

We have isolated and sequenced genes from Saccharomyces cerevisiae (SRP54 ~) and Schizosaccharomyces pombe (SRP54"p) encoding proteins homologous to both the 54-kD protein subunit (SRP54 re'm) of the mammalian signal recognition particle (SRP) and the product of a gene of unknown function in Escherichia coli, flh (Rtmisch, K., J. Webb, J. Herz, S. Prehn, R. Frank, M. Vingron, and B. Dobberstein...

A human Cds1-related kinase that functions downstream of ATM protein in the cellular response to DNA damage.

Checkpoints maintain the order and fidelity of the eukaryotic cell cycle, and defects in checkpoints contribute to genetic instability and cancer. Much of our current understanding of checkpoints comes from genetic studies conducted in yeast. In the fission yeast Schizosaccharomyces pombe (Sp), SpRad3 is an essential component of both the DNA damage and DNA replication checkpoints. The SpChk1 a...

Apoptosis-like yeast cell death in response to DNA damage and replication defects.

In budding (Saccharomyces cerevisiae) and fission (Schizosaccharomyces pombe) yeast and other unicellular organisms, DNA damage and other stimuli can induce cell death resembling apoptosis in metazoans, including the activation of a recently discovered caspase-like molecule in budding yeast. Induction of apoptotic-like cell death in yeasts requires homologues of cell cycle checkpoint proteins t...